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Why We Include Pharmacogenomic Testing

One of the issues in psychiatry today is the lack of personalization. Physicians have historically used a “one size fits all” approach to prescribing medications, even though we know that women and minorities do not process antidepressants the same way as white men.

One of the issues in psychiatry today is the lack of personalization. Physicians have historically used a “one size fits all” approach to prescribing medications, even though we know that women and non-white individuals do not process antidepressants the same way as white men.

At Prairie, we are tackling this issue by using pharmacogenomic testing, a form of genetic testing that looks at the relationship between genetic variations and medication. While genetic testing cannot pick the perfect medication for patients, it helps physicians plan treatments, resulting in various benefits such as fewer side effects, lower costs, and faster recoveries for patients.

Here, we discuss the reasons why genetic testing works and how it helps physicians prescribe medications.

How do your genes relate to mental health medications?

We know that some enzymes play a large role in drug metabolism. However, individuals may have different variations of these enzymes, which affects the way they process, or metabolize, drugs. These variations are common; over 90% of people have at least one variant that could impact their treatment.

Six enzymes account for approximately 90% of drug metabolism. As a result, it’s possible to understand how an individual processes medication just by understanding the variations in their enzymes. One way to do so is by using a patient’s genetics.

Single nucleotide polymorphisms (SNPs, pronounced “snips”) are the most common form of genetic variation. DNA is composed of four different building blocks; a SNP occurs when one building block is substituted for another. Generally, genetic variants are defined by SNPs in a person’s genes.

These differences in genes correspond to differences in the enzymes that a person produces. The variants are linked to the speed at which a person metabolizes medication, which is particularly useful for understanding the appropriate dosage a person needs. This is helpful to physicians because many patients take antidepressants at inappropriate dosages, especially if their medication was prescribed by a primary care physician rather than a psychiatrist.

(To learn more about the science behind pharmacogenomic testing, read about the genes examined in your genetic test.)

Image Caption: Patients often encounter side effects when taking medications. In a recent randomized controlled trial, compared to the experimental group, 1.5 times as many patients in the control group had side effects that justified a change in medication. (source)

How do doctors use genetic testing?

Once physicians understand the variations in their patients’ enzymes, they are able to make more informed decisions about which medications and dosages to use. This isn’t to say that pharmacogenomic testing can pick the perfect medication for doctors; however, the insights that testing provides have been clinicallyprovento help patients.

For example, if a patient metabolizes an antidepressant slower than average due to variations in their genetics, then the antidepressant will stay in their body for longer. As a result, there is a higher chance that their medication will result in adverse side effects like nausea, weight gain, and fatigue. By knowing a patient’s metabolic profile, physicians can avoid prescribing too much of an antidepressant, allowing the patient to avoid adverse side effects.

To make these decisions, our psychiatrists only use recommendations that have been validated by groups such as the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Image Caption: The contents of our Welcome Kit, which includes a saliva-based DNA collection tool in addition to more information about our service.

Pharmacogenomic testing has clear benefits in psychiatry

Remedying the “trial and error” approach to psychiatry has been an active field of research for decades. Genetic testing is one way forward; by identifying the genetic variants in their patients, doctors are able to make more informed treatment decisions. This results in real benefits for patients. For psychiatry in particular, patients see greater reductions in their symptoms, lower healthcare costs, and fewer side effects. This is especially true for patients who have found their previous antidepressants to be intolerable or ineffective.

These benefits speak for themselves. That’s why we provide pharmacogenomic tests to every one of our members, who are shipped DNA kits after meeting with a Care Partner. After the member sends their spit sample to our accredited partner lab, our psychiatrists receive a report to help guide treatment.

Ultimately, our number one priority is our members and their mental health. We give our members every evidence-based opportunity to get better, which includes using pharmacogenomic testing to provide personalized treatment. It’s just one more way we’re making mental healthcare more effective. Wondering if you are likely to benefit from genetic testing? Take our free pharmacogenomics quiz to find out.

Take The Pharmacogenomics Quiz

Mon Jul 06 2020

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